Conformational Isomerism Can Limit Antibody Catalysis

Conformational isomerism of trans-[Pt(NH[subscript

X-ray crystallographic analysis of the compound trans-[Pt(NH2C6H11)2I2] revealed the presence of two distinct conformers within one crystal lattice. This compound was studied by variable temperature NMR spectroscopy to investigate the dynamic interconversion between these isomers. The results of this investigation were interpreted using physical (CPK) and computational (molecular mechanics and ...

Antibody catalysis

It has recently become possible to exploit the diversity and specificity of the humeral immune system to create immunoglobulins capable of catalysis. Generation and characterization of catalytic antibodies for three concerted chemical reactions in which carbon-carbon bonds are made or broken are briefly reviewed. The production of monoclonal antibodies with tailored catalytic properties is a pr...

Conformational Isomerism in l , Substituted Derivatives of 3 , 3 . Dimethylbutane

The Influence of Conformational Isomerism on Drug Action and Design

COURSE INFORMATION The following text is a summary of a two-hour lecture sequence presented in the course, Advanced Medicinal Chemistry I. This course is required for all MS and PhD students in Duquesne University’s Medicinal Chemistry Graduate Program. It is also available as an elective for undergraduate students in their last semester of didactic work. The course emphasizes the basic chemica...

Limit to high-spin isomerism in hafnium isotopes

Configuration-constrained nuclear shape calculations are used to show that reinforcing neutron and proton orbital structures create exceptional conditions for the formation of multiquasiparticle isomers in neutron-rich hafnium isotopes, with axially symmetric, prolate shapes. Highly excited, long-lived states are predicted. However, at angular momenta close to 40\ , orbital alignment effects fo...